2024 Release Notes¶
Release 6.4.1¶
Release date: November 18, 2024
Updates
- Hotfix to update loci file, see known issues for further details
Release 6.4.0¶
Release date: October 23, 2024
Updates
- High resolution somatic coverage plots are now available
- Somatic small and germline small variants have a link-out to SpliceAI
- Genes have a link-out to The Cancer Genome Atlas from the variant details page
- Bug fixes
Release 6.3.0¶
Release date: September 25, 2024
Updates
- IGV link outs to both variant coordinates are now included for structural variants with more than one coordinate e.g., translocations
- Bug fixes including correctly displaying the variant type for internal tandem duplications
Release 6.2.0¶
Release date: July 10, 2024
Updates
- Variants can now be filtered by their mode of action. Further details for somatic small, somatic structural and copy number and germline small variants can be seen under the "Filters" and "Applying Filters" tabs
- Variants link out to specific entries in Varsome from the variant details page for somatic small, somatic copy number and germline small variants
- Useful Resources for structural variants include a link out to the Varsome home page
- Genes have a link-out to My Cancer Genome from the variant details page
- The Cellbase version and the Cancer Tiering Pipeline Version are now displayed in the case summary under "Additional Information"
Release 6.1.0¶
Release date: June 19, 2024
Updates
- We have implemented accessibility changes including changes of text colour, additional attributes for screen readers, re-styling focus, hover and click states for interactive elements and re-positioning some page elements to facilitate user experience, colour contrast and colour blindness support
- The structural and copy number variant list are now using the latest GEL population frequencies
- We have added our UKAS accreditation to the cDSS
Release 6.0.0¶
Release date: April 24, 2024
Updates
- We have removed the coupling of Biological Classification and AMP tier when adding variant interpretations
- The functionality to download a PDF export has been removed from the export preview page
- The cDSS can now support multiple analyses under a single referral, therefore a unique case id is used in the URL for each referral For backwards compatibility, the case summary page will redirect from any old referral id to the new case id
- Bug fixes including CNV and SV sizes shown in BP instead of KB
Info
Variant filtering for reported variants in tumour first cases in the cDSS may differ from that in HTMLs: in these cases, we apply both somatic and germline prioritisation algorithms to all variants with GEL internal population germline allele frequency under 2%, so all such variants will appear on the cDSS. In the HTMLs and CSV tables, all variants with either GEL internal or gnomAD population germline allele frequency over 1% and no potential effect on cancer predisposition genes (nothing in the "Interpretation as germline" field) are filtered out. We are currently working on fully harmonising the variant lists between cDSS and HTML, and this discrepancy should disappear soon.
Release 5.1.2¶
Release date: March 13, 2024
Updates
- Bug fixes including fixing the redirection from the IP to Case Summary Page when opening a case